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Glycine
Propionyl-L-Carnitine HCL, USP (GlycoCarn®)
for Human Health and Performance
Dietary supplementation with the naturally
occurring nutrient L-carnitine has been
extensively studied as an aid to improve
fatty acid metabolism and aerobic exercise
capacity, to provide antioxidant benefits,
and to enhance blood flow to active tissues
(e.g., skeletal muscle and heart). While
multiple forms of carnitine have been studied
and are currently available, Propionyl-L-Carnitine
(PLC) has been shown to best support healthy
heart and skeletal muscle function. A patented
and safe USP dietary form of PLC has been
developed which is molecularly bonded to
glycine, one of the precursor amino acids
to carnitine biosynthesis. This form is
known as Glycine Propionyl-LCarnitine (GPLC)
or GlycoCarn®, and is one
of the AminoCarnitines® branded
and marketed by Sigma-Tau HealthScience.
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The
New L-Carnitine With a Focus on Muscle and
Energy
Sometimes, a well-known and valued supplement
can be transformed to provide significant
new benefits. Such is the case with L-carnitine.
Propionyl-L-carnitine is a form that until
very recently was restricted to medical
uses. Now it finally is available more generally
as glycine propionyl-L-carnitine or Glycocarn®,
USP, which is a patented compound. Many
health food shoppers will be surprised by
the difference found with this next generation
of L-carnitine. This is the L-carnitine
with a focus on muscular energy, exercise
recovery and reduced fatigue. |
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Metabolic
Cardiology - It's All About ATP - Part 2
Last month we chatted with Dr. Stephen Sinatra
about new nutrients to keep the heart and
arteries healthy, particularly a nutrient
called propionyl- L-carnitine (PLC). This
month, we will focus on metabolic cardiology
and how adenosine triphosphate (ATP), and
thus its precursors, the carnitines, CoQ-10
and D-ribose, is the bottom line in heart
health. Anybody with any type of cardiovascular
disease has a heart that is always leaking
ATP. The body can’t make it back fast
enough by de novo (from the beginning) synthesis!
It takes too long and the ATP leakage is
faster. It’s all about ATP and less
about oxygen! |
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Understanding
L-Carnitine
Carnitine exists in two isomeric forms:
l-carnitine and d-carnitine. The latter
has no physiological role other than acting
as a competitive inhibitor of l-carnitine,
the only isomer biologically active and
with a fundamental role in the utilization
of lipid substrates by the cellular mitochondria.
There are in the marketplace other sources
of d- or dl-carnitine of highly improbable
efficacy and, in the case of d-carnitine,
not allowed for food or feed use. Sigma-tau
HealthScience does not now nor has it ever
been a supplier of any forms of carnitine
other than the pure l-carnitine form. L,
dl- and l-isomers can be distinguished optically
by using refractometric techniques that
determine the specific rotation and therefore
the optical purity of the isomer. Sigma-tau
HealthScience l-carnitine meets or exceeds
all USP as well as other existing codex
requirements for optical purity and, of
course, other codex parameters. |
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